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Compared with mouse thymocytes, mouse ES cells comprise larger ranges of total genomic H3K4me3 and have increased H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In settlement with this, international decreases in H3K4me3 ranges occur during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven As well as, there are dynamic modifications in H3K4me3 profiles at particular units of genes throughout ES cell differentiation.
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